circTUBGCP5 promotes liver cancer progression and glycolysis by up-regulating the expression of ACSL4

Abstract A large number of researches have shown that circular RNA (circRNA) is new hope for the diagnosis or treatment tumors, including liver cancer (LCa). However, it remains largely unclear role circRNA in progression LCa and its molecular mechanism. GSE164803 microarray dataset was applied to identify dysregulated circRNAs noncancerous tissues. CircTUBGCP5 (hsa_circ_0034049) selected further research. Biological functions circTUBGCP5 were investigated by EdU, colony formation, flow cytometry, glucose consumption lactate production assay, vivo tumorigenesis. pull-down assay dual-luciferase reporter used investigate interaction between circTUBGCP5, miR-144-3p, ACSL4. We demonstrated significantly up-regulated tissues cells. promoted cell proliferation, anti-apoptotic ability, glycolysis, tumorigenesis at least partially sponging miR-144-3p regulate ACSL4 protein level. In conclusion, a forceful contributor malignant behaviors glycolysis via modulating circTUBGCP5/miR-144-3p/ACSL4 axis, which has provided target patients.